A case of immune thrombocytopaenia induced by pembrolizumab in a metastatic melanoma patient with a history of immune-mediated pure red cell aplasia

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Immune checkpoint blocking agents such as the PD1-antagonist pembrolizumab have been approved for the treatment of metastatic melanoma [1]. Owing to its mechanism of action, this drug restores tumour-specific T-cell response and may induce various types of immune-related adverse events (irAEs) [2]. Haematological toxicities are rare, and cytopenia of autoimmune origin remain exceptional. We report, herein, the occurrence of successive haematologic adverse events in a patient treated with pembrolizumab for a metastatic melanoma including an immune-mediated pure red cell aplasia (PRCA) followed by an immune thrombocytopaenia (IT).

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