A patient with pembrolizumab-induced fatal polymyositis

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Regulatory approval for the anti-programmed death 1 (PD-1) receptor monoclonal antibody (mAb) pembrolizumab represented a major therapeutic advance for patients with metastatic solid cancers [1]. As anticipated, immune checkpoint blockade of the PD-1/programmed death-ligand 1 (PD-L1) axis leads to unchecked immune responses and the development of autoimmune manifestations, referred to as immune-related adverse events (irAEs) [1]. Herein, we report a patient with metastatic urothelial carcinoma treated with pembrolizumab who developed fatal polymyositis (PM).

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