Cell-Intrinsic Wnt4 Influences Conventional Dendritic Cell Fate Determination to Suppress Type 2 Immunity [INNATE IMMUNITY AND INFLAMMATION]

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Key Points

  • Wnt4 is a noncanonical Wnt protein that is expressed in stroma and cDC.

  • Wnt4 is both necessary and sufficient for maintenance of cDC1.

  • Lack of DC-derived Wnt4 accelerates type 2 immunity.

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