IL-25 Orchestrates Activation of Th Cells via Conventional Dendritic Cells in Tissue to Exacerbate Chronic House Dust Mite-Induced Asthma Pathology [MUCOSAL IMMUNOLOGY]

Key Points

  • IL-25 contributes to specific disease phenotypes in chronic HDM-induced asthma.

  • Lung remodeling is partly dependent on IL-25 signaling in cDCs and in Th cells.

  • IL-25 induces clustering of Th9 T cells next to IL-25–activated cDCs in airways.

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