The Otubain YOD1 Suppresses Aggregation and Activation of the Signaling Adaptor MAVS through Lys63-Linked Deubiquitination [IMMUNE REGULATION]

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Key points

  • The otubain YOD1 fine-tunes MAVS-RLR pathway–mediated antiviral immunity.

  • YOD1 interacts with MAVS on mitochondria.

  • YOD1 deubiquitinates MAVS and abrogates aggregation of MAVS.

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