Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus [INFECTIOUS DISEASE AND HOST RESPONSE]

11 gennaio 2022 Senza categoria
Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus [INFECTIOUS DISEASE AND HOST RESPONSE]
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Key Points

  • Altered mitochondrial homeostasis in SLE neutrophils impairs superoxide production.

  • NET formation by SLE neutrophils is decreased in response to S. aureus.

  • SLE neutrophils are less bactericidal towards S. aureus.

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