Amelioration of Graft-versus-Host Disease by Exopolysaccharide from a Commensal Bacterium [IMMUNE REGULATION]

Key Points

  • EPS treatment increases survival of mice undergoing GvHD from 10 to 70%.

  • EPS induces inhibitory BMDCs that inhibit alloreactive T cell proliferation in MLR.

  • Inhibitory activity of EPS–BMDCs is mediated by IDO.

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