Deletion of IRF4 in Dendritic Cells Leads to Delayed Onset of T Cell-Dependent Colitis [MUCOSAL IMMUNOLOGY]

Key Points

  • IRF4-expressing cDC2 promote early T cell–dependent colitis.

  • IRF4-expressing cDC2 promote the generation of colitogenic CD4+ T cells.

  • IRF4-expressing cDC2 are not required for Treg-mediated suppression of colitis.

  • Lascia un commento