Editorial for Cribriform architecture prostatic adenocarcinoma in needle biopsy is a strong independent predictor for lymph node metastases in radical prostatectomy (M. Downes et al.) and Ductal variant prostate carcinoma is associated with a significantly shorter metastasis-free survival (K. Chow et al.)

In this volume of the European Journal of Cancer, two complementary studies regarding the histopathology of Gleason grade IV (GG4) prostate cancer (PCa) are presented. Herein, the authors explore specific histopathological aspects of GG4 PCa predictive of poor outcome and lymph node status. The common message underlined by both reports is that features accessible via routine histology of prostate biopsy or prostatectomy specimens yield valuable information regarding both patient outcome and specific molecular changes.

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