Hypoxia-Inducible Factor {alpha} Subunits Regulate Tie2-Expressing Macrophages That Influence Tumor Oxygen and Perfusion in Murine Breast Cancer [TUMOR IMMUNOLOGY]

Key Points

  • HIF-α subunits differentially regulate Tie2 expression on macrophages.

  • Myeloid HIF-1α deficiency enhances tumor oxygenation and chemotherapeutic response.

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