Identification and Characterization of Zebrafish Tlr4 Coreceptor Md-2 [INNATE IMMUNITY AND INFLAMMATION]

Key Points

  • We found a gene for Md-2, a key protein that senses bacterial products, in zebrafish.

  • Zebrafish Md-2 has functional and physiological similarities to amniote MD-2.

  • LPS sensing in zebrafish may be more similar to humans than previously thought.

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