Influenza Infection Induces Alveolar Macrophage Dysfunction and Thereby Enables Noninvasive Streptococcus pneumoniae to Cause Deadly Pneumonia [INFECTIOUS DISEASE AND HOST RESPONSE]

Key Points

  • Influenza enables noninvasive Streptococcus pneumoniae to cause deadly pneumonia.

  • Influenza mainly predisposes hosts to airway, but not systemic, bacterial infection.

  • Influenza temporally abolishes innate bacterial clearance by alveolar macrophages.

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