Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-{beta} Receptor III Binding and Activation of Membrane-Bound TGF-{beta} [IMMUNE REGULATION]

Key Points

  • Lactoferrin induces Foxp3+ Tregs via TβRIII->ROS->mTGF-β activation->Smad3 signaling.

  • Suppression by these Tregs exerts through CD39/CD73-mediated adenosine generation.

  • Peroral administration of lactoferrin alleviates DSS-induced colitis.

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