Letter to the Editor: Comments on ERCC3 as a new ovarian cancer susceptibility gene

We have read with interest the article by Stradella et al. [1], suggesting ERCC3 as a new gene predisposing the hereditary breast (BC) and ovarian (OC) cancer. The authors identified 13 ERCC3 mutation carriers among 1311 patients with hereditary breast and/or ovarian cancer (HBOC; 0.99%), while the mutation burden in Spanish controls was four times lower (0.22%) and corresponded to European non-Finnish GnomAD controls (0.24%). The authors found a significant association of ERCC3 mutations with OC risk.

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