Loss of mTORC2 Activity in Neutrophils Impairs Fusion of Granules and Affects Cellular Metabolism Favoring Increased Bacterial Burden in Sepsis [INNATE IMMUNITY AND INFLAMMATION]

Key Points

  • Fusion of granules is compromised in Rictor-deleted neutrophils.

  • Disruption of mTORC2 signaling in neutrophils decreases HOCl.

  • Loss of mTORC2 activity in neutrophils impairs their microbicidal capacity.

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