Metabolic Adaptation of Macrophages as Mechanism of Defense against Crystalline Silica [INNATE IMMUNITY AND INFLAMMATION]

Key Points

  • Crystalline silica induces an immunometabolic response in RAW 264.7 macrophages.

  • Silica induces macrophages activation without requiring LPS priming.

  • Mitochondrial complex II is crucial for macrophage response and survival to silica.

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