NUDT21 Links Mitochondrial IPS-1 to RLR-Containing Stress Granules and Activates Host Antiviral Defense [INNATE IMMUNITY AND INFLAMMATION]

Key Points

  • NUDT21 forms a complex with mitochondrial IPS-1.

  • NUDT21 mediates IPS-1 localization to SGs upon poly(I:C) transfection.

  • NUDT21 plays a key role in induction of IFN-β in response to virus infection.

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