Overexpression of SH2-Containing Inositol Phosphatase Contributes to Chronic Lymphocytic Leukemia Survival [IMMUNE REGULATION]

Key Points

  • B cell–specific deletion of Ship2 phosphatase reduces CLL formation in a mouse model.

  • Ship2 inhibition reduces Akt/mTORC1/S6 signaling in murine and human CLL cells.

  • Ship2 supports survival of CLL cells via the key antiapoptotic protein Mcl-1.

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