Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPK{alpha}1-ULK1-ATG7 Pathways [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

21 dicembre 2021 Senza categoria
Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPK{alpha}1-ULK1-ATG7 Pathways [MOLECULAR AND STRUCTURAL IMMUNOLOGY]
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Key Points

  • IL-2 and IL-7 induce S6Kstrong and S6Kweak signals, leading to forming TE and TM cells.

  • IL-7–stimulated S6Kweak signaling controls T cell memory via FOXO1 and AMPK pathways.

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