TRAF3 in T Cells Restrains Negative Regulators of LAT to Promote TCR/CD28 Signaling [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

Key Points

  • TRAF3 is recruited to the TCR/CD28 complex and interacts with LAT.

  • TRAF3 enhances TCR/CD28 signaling and restrains the negative LAT regulator Dok1.

  • TCR-induced kinase activation in TRAF3–/– T cells is enhanced by inhibiting PTP1B.

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