Ubiquitin Specific Protease 1 Expression and Function in T Cell Immunity [INFECTIOUS DISEASE AND HOST RESPONSE]

Key Points

  • Usp1 is expressed in activated T cells and interacts with Id2 and Id3.

  • Usp1 loss affects CD8+ T cells responding to secondary but not primary infection.

  • Usp1-deficient memory CD8+ T cells have diminished Id2 protein and proliferation.

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