V Region of IgG Controls the Molecular Properties of the Binding Site for Neonatal Fc Receptor [MOLECULAR AND STRUCTURAL IMMUNOLOGY]

Key Points

  • IgG1 Abs with different V regions bind to FcRn with different affinity.

  • The V region of IgG1 dictates the mechanism of molecular recognition by FcRn.

  • Formation of immune complexes modifies the mechanism of IgG binding to FcRn.

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